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Description

The change of objective function value (OFV) was used as the covariate inclusion criteria

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Key findings from SURMOUNT-1 include a mean weight loss of 15.0% at the 5mg dose, 19.5% at the 10mg dose, and 20.9% at the 15mg dose over 72 weeks

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Nat Chem Biol (2016) 12(9):68693

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Collectively, our results indicated that IGF-1 protected NF-B pathway by suppression of PI3K/Akt and MAPKs specific pathways

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